Description

2-Methyl-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a fused pyrrolopyridine ring system and a trifluoromethyl group, makes it a critical intermediate for developing novel bioactive molecules. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for creating new drug candidates and crop protection agents with enhanced metabolic stability and binding properties.

Application

• Pharmaceutical Intermediate: A key scaffold in the synthesis of potential kinase inhibitors, receptor antagonists, and other small-molecule therapeutics targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used as a building block for developing new generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a specialized monomer or ligand in the development of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	2-Methyl-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine
CAS No.	905273-82-7
Molecular Formula	C9H9F3N2
Molecular Weight	202.18 g/mol
Synonyms	2-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1H-pyrrolo[3,4-b]pyridine; 6,7-Dihydro-2-methyl-3-(trifluoromethyl)-5H-pyrrolo[3,4-b]pyridine; 905273-82-7; 2-Methyl-3-trifluoromethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine; 3-(Trifluoromethyl)-2-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting your regulatory and research needs. A detailed Certificate of Analysis (COA) with batch-specific results from HPLC, NMR, and MS is available for each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong alkalis and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.