Description

2-(Methoxycarbonyl)Cyclobutane-1-Carboxylic Acid is a high-purity cyclobutane derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures with precise stereochemistry, enabling the development of novel active pharmaceutical ingredients (APIs) and specialty materials. Pharmaceutical research organizations and fine chemical manufacturers need it for applications in medicinal chemistry, particularly in the synthesis of constrained analogs and peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including protease inhibitors and other small molecule drugs.
• Medicinal Chemistry: Used to introduce the constrained cyclobutane ring system, a valuable scaffold for improving metabolic stability and binding affinity in drug candidates.
• Peptidomimetic Synthesis: Serves as a backbone or side-chain component in the design of peptide mimics to enhance bioavailability and pharmacological properties.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to produce enantiomerically pure compounds.
• Material Science Research: Investigated as a monomer or precursor for the synthesis of specialized polymers with unique thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the construction of molecular probes for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	2-(Methoxycarbonyl)Cyclobutane-1-Carboxylic Acid
CAS No.	904236-21-1
Molecular Formula	C7H10O4
Molecular Weight	158.15 g/mol
Synonyms	Methyl 1-Carboxycyclobutane-2-carboxylate; Cyclobutane-1,2-dicarboxylic Acid 2-Methyl Ester; 1-Carboxy-2-(methoxycarbonyl)cyclobutane; 2-(Methoxycarbonyl)cyclobutane-1-carboxylic acid; Cyclobutane-1-carboxylic acid, 2-(methoxycarbonyl)-; Methyl 2-carboxycyclobutane-1-carboxylate; Cyclobutane-1,2-dicarboxylic acid monomethyl ester
EINECS	Contact for details

Quality Control

Our 2-(Methoxycarbonyl)Cyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.