Description

3,5-Difluoroisonicotinic Acid is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which introduces fluorine atoms at strategic positions to modulate the electronic and steric properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where fluorination enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers for electronic applications.
• Chemical Biology Probes: Utilized to create fluorinated analogs of biomolecules for metabolic studies and imaging applications.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3,5-Difluoroisonicotinic Acid
CAS No.	903522-29-2
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	3,5-Difluoropyridine-4-carboxylic Acid; 4-Pyridinecarboxylic acid, 3,5-difluoro-; 3,5-Difluoro-4-pyridinecarboxylic Acid; Isonicotinic acid, 3,5-difluoro-; 3,5-Difluoropyridine-4-carboxylic acid; 3,5-Difluoro-4-carboxypyridine
EINECS	Contact for details

Quality Control

Our 3,5-Difluoroisonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed and under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.