Description

4-Bromo-2,6-Difluoropyridine is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of halogen and fluorine substituents, which enable precise cross-coupling reactions and facilitate the introduction of complex functionalities into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing difluoropyridine motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its electron-deficient aromatic core.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and Negishi couplings to form biaryl structures.
• Fluorine Chemistry: The fluorine atoms provide metabolic stability and influence lipophilicity, making it valuable for medicinal chemistry optimization.

Basic Information

Product Name	4-Bromo-2,6-Difluoropyridine
CAS No.	903513-58-6
Molecular Formula	C5H2BrF2N
Molecular Weight	193.98 g/mol
Synonyms	2,6-Difluoro-4-bromopyridine; 4-Bromo-2,6-difluoropyridine; Pyridine, 4-bromo-2,6-difluoro-; 903513-58-6; 4-Br-2,6-F2-Py
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,6-Difluoropyridine is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its fluoride/strong alkali chemical property, ensure it is stored separately from bases and moisture-sensitive reagents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.