Description

13-Bromospiro[Cyclohexane-4,3'-Indoline]-1-Ene is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic indoline scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential biological activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for synthesizing novel drug candidates and other specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization programs to explore structure-activity relationships (SAR) around the spirocyclic indoline core.
• Agrochemical Development: Serves as a precursor for creating new active ingredients with potential herbicidal or insecticidal properties.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex organic molecules for material science and specialty chemical applications.
• Academic Research: Used in university and institutional labs for methodological studies in organic synthesis and heterocyclic chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development projects.

Basic Information

Product Name	13-Bromospiro[Cyclohexane-4,3'-Indoline]-1-Ene
CAS No.	902137-93-3
Molecular Formula	C14H16BrN
Molecular Weight	278.19 g/mol
Synonyms	13-Bromospiro[cyclohexane-4,3'-indoline]-1-ene; 1H-Indole, 2,3-dihydro-1'-(bromomethylene)spiro[cyclohexane-4,3'-[3H]indol]-1-one (related); Spiro[cyclohexane-4,3'-indoline]-1-ene, 13-bromo-; 13-Bromo-1-azaspiro[4.5]deca-1,6,9-trien-8-one (possible tautomer); Bromospiroindoline; Advanced Spirocyclic Indoline Intermediate
EINECS	Contact for details

Quality Control

Every batch of 13-Bromospiro[Cyclohexane-4,3'-Indoline]-1-Ene is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.