Description

5-Cyclopropylnicotinonitrile is a high-purity, versatile nitrile-substituted pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling the introduction of the cyclopropyl and nitrile pharmacophores. Pharmaceutical, agrochemical, and material science R&D laboratories require this intermediate for constructing complex molecular architectures with potential biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Development: Used in the research and production of advanced herbicides and fungicides, leveraging the bioactivity of the pyridine-cyclopropane scaffold.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers due to its conjugated system and electron-withdrawing nitrile group.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental building block supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	5-Cyclopropylnicotinonitrile
CAS No.	900802-81-5
Molecular Formula	C9H8N2
Molecular Weight	144.18 g/mol
Synonyms	5-Cyclopropyl-3-pyridinecarbonitrile; 3-Cyano-5-cyclopropylpyridine; Nicotinonitrile, 5-cyclopropyl-; 5-Cyclopropylpyridine-3-carbonitrile; 3-Pyridinecarbonitrile, 5-cyclopropyl-; 5-Cyclopropyl-3-cyanopyridine
EINECS	Contact for details

Quality Control

Every batch of 5-Cyclopropylnicotinonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade meets a typical purity specification of ≥97% (by HPLC), with higher purity grades available. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, related substances, and residual solvents is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.