Description

3-Bromo-5-Iodo-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in pharmaceutical discovery and materials science. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable source of high-purity intermediates for drug candidate synthesis and functional material development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents, leveraging the reactivity of both bromo and iodo substituents for sequential cross-coupling reactions.
• Agrochemical Research: Used in the development of novel active ingredients, where the fused pyrrolopyridine scaffold can contribute to unique biological activity profiles.
• Material Science: Acts as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tags for studying biological systems and protein interactions.
• Cross-Coupling Reactions: The halogen atoms are prime sites for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Buchwald-Hartwig), making it a versatile scaffold for library synthesis.
• Ligand Synthesis: Useful for constructing complex nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Product Name	3-Bromo-5-Iodo-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	900514-06-9
Molecular Formula	C7H4BrIN2
Molecular Weight	322.93 g/mol
Synonyms	3-Bromo-5-iodo-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-5-iodo-; 900514-06-9; 3-Br-5-I-1H-pyrrolo[2,3-b]pyridine; 5-Iodo-3-bromo-1H-pyrrolo[2,3-b]pyridine; 3-Bromo-5-iodo-7-azaindole; 3-Bromo-5-iodo-1H-7-azaindole
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Iodo-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.