Description

5-Chloromethyl-1H-Pyrrolo[2,3-B]Pyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with significant synthetic utility. This compound is a crucial building block in modern medicinal chemistry, valued for its role in constructing complex heterocyclic scaffolds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Organic Synthesis Building Block: Serves as a versatile reagent for constructing fused pyrrolopyridine systems, a privileged structure in drug discovery.
• Bioconjugation & Probe Development: The reactive chloromethyl group enables its use in creating labeled compounds for biochemical assays and diagnostic tools.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for methodological development and exploring new chemical spaces.

Basic Information

Product Name	5-Chloromethyl-1H-Pyrrolo[2,3-B]Pyridine Hydrochloride
CAS No.	900514-05-8
Molecular Formula	C9H8Cl2N2
Molecular Weight	215.08 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-(chloromethyl)-, hydrochloride (1:1); 5-(Chloromethyl)-1H-pyrrolo[2,3-b]pyridine hydrochloride; 5-(Chloromethyl)-7-azaindole hydrochloride; 5-Chloromethyl-7-azaindole HCl; 5-Chloromethyl-1H-pyrrolo[2,3-b]pyridine HCl; 900514-05-8; 5-(Chloromethyl)-1H-pyrrolo[2,3-b]pyridinium chloride
EINECS	Contact for details

Quality Control

Our 5-Chloromethyl-1H-Pyrrolo[2,3-B]Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance in cGMP and ISO 9001 environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.