Description

1-Boc-4-(3-Ethoxycarbonyl-Pyridin-2-Yl)-Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core protected by a Boc (tert-butoxycarbonyl) group and substituted with a functionalized pyridine moiety. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with precise structural control for drug discovery and development. It is primarily needed by research institutions, pharmaceutical companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for lead optimization in drug discovery programs.
• CNS Drug Development: Serves as a building block for compounds targeting neurological receptors and enzymes due to its piperazine and heterocyclic structure.
• Peptidomimetics Synthesis: Employed in the design and synthesis of peptide analogs and mimetics to improve metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Scale-Up: A critical material for contract research and manufacturing organizations (CROs/CMOs) offering custom synthesis services from milligram to kilogram scale.

Basic Information

Product Name	1-Boc-4-(3-Ethoxycarbonyl-Pyridin-2-Yl)-Piperazine
CAS No.	900183-95-1
Molecular Formula	C17H25N3O4
Molecular Weight	335.40 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-(3-ethoxycarbonyl-2-pyridyl)piperazine; tert-Butyl 4-(3-(ethoxycarbonyl)pyridin-2-yl)piperazine-1-carboxylate; 2-(1-Boc-piperazin-4-yl)-3-pyridinecarboxylic acid ethyl ester; 1-Boc-4-(3-carbethoxy-2-pyridyl)piperazine; N-Boc-4-(3-ethoxycarbonylpyridin-2-yl)piperazine; Boc-4-(3-EtO2C-pyridin-2-yl)-piperazine; 900183-95-1; Piperazine, 1-(1,1-dimethylethoxy)carbonyl-4-(3-ethoxycarbonyl-2-pyridinyl)-
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(3-Ethoxycarbonyl-Pyridin-2-Yl)-Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to minimize exposure to atmospheric moisture and light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.