Description

(1R,3Ar,4Ar,8Ar,9S,9Ar)-1-Methyl-3-Oxodecahydro-3H-Spiro[Naphtho[2,3-C]Furan-6,2'-[1,3]Dioxolane]-9-Carboxylic Acid is a high-purity, complex spirocyclic organic compound with a defined stereochemistry. This molecule serves as a critical advanced intermediate in the synthesis of sophisticated active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily required by pharmaceutical R&D laboratories and custom synthesis facilities engaged in developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial manufacturing of target APIs.
• Asymmetric Synthesis: Leveraged in stereoselective reactions due to its defined (1R,3Ar,4Ar,8Ar,9S,9Ar) configuration to introduce molecular complexity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in regulatory filings.
• Fine Chemical Synthesis: A precursor for specialized ligands, catalysts, or other high-value, low-volume specialty chemicals.

Basic Information

Product Name	(1R,3Ar,4Ar,8Ar,9S,9Ar)-1-Methyl-3-Oxodecahydro-3H-Spiro[Naphtho[2,3-C]Furan-6,2'-[1,3]Dioxolane]-9-Carboxylic Acid
CAS No.	900161-13-9
Molecular Formula	C19H26O6
Molecular Weight	350.41 g/mol
Synonyms	1-Methyl-3-oxodecahydro-3H-spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid; (1R,3aR,4aR,8aR,9S,9aR)-1-Methyl-3-oxododecahydrospiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid; Spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid derivative; CAS 900161-13-9; Advanced Spirocyclic Intermediate; Chiral Spiroketal Acid Intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and purity. All materials are characterized using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment. We support cGMP compliance for pharmaceutical applications, with documentation tailored to meet regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.