Description

1-(tert-Butoxycarbonyl)-5,5-Dimethylpyrrolidine-2-Carboxylic Acid is a high-purity, protected amino acid derivative widely used as a critical building block in advanced organic synthesis. This compound is essential for the development of novel pharmaceuticals and bioactive molecules, offering a versatile scaffold for peptide and peptidomimetic chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the synthesis of complex organic targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and metabolic disorders.
• Peptide Synthesis: Serves as a protected proline analog for the solid-phase and solution-phase synthesis of custom peptides and peptidomimetics.
• Chemical Research: Used as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in the scale-up and development of robust synthetic routes for complex organic molecules under GMP-like conditions.
• Bioconjugation: Acts as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Academic Research: A valuable reagent for universities and research institutes studying heterocyclic chemistry and novel synthetic methodologies.

Basic Information

Product Name	1-(tert-Butoxycarbonyl)-5,5-Dimethylpyrrolidine-2-Carboxylic Acid
CAS No.	900158-99-8
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	Boc-5,5-Dimethylproline; Boc-Dimethylproline-OH; 1-Boc-5,5-dimethylpyrrolidine-2-carboxylic acid; 5,5-Dimethyl-L-proline, 1-(1,1-dimethylethyl) ester; tert-Butyl 5,5-dimethyl-2-carboxypyrrolidine-1-carboxylate; (S)-1-((tert-Butoxy)carbonyl)-5,5-dimethylpyrrolidine-2-carboxylic acid; N-Boc-5,5-dimethylproline
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)-5,5-Dimethylpyrrolidine-2-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0% (Total impurities ≤3.0%)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.