Description

Ethyl 6-Iodo-2-(Trifluoromethyl)Imidazo[1,2-A]Pyridine-3-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its core value lies in the strategic combination of an iodine substituent and a trifluoromethyl group on the imidazopyridine scaffold, enabling versatile derivatization and the introduction of desirable physicochemical properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of novel active ingredients, particularly for targeted therapies and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in oncology, CNS disorders, and anti-infective research, leveraging the bioisosteric properties of the trifluoromethyl group.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the iodine atom allows for further cross-coupling reactions to create diverse compound libraries.
• Material Science Precursor: Serves as a specialized monomer or ligand precursor for creating advanced organic electronic materials or metal-organic frameworks (MOFs).
• Chemical Biology Probe: Utilized in medicinal chemistry for creating labeled compounds or photoaffinity probes due to the reactivity of the iodine handle.
• Cross-Coupling Reactions: The aryl iodide moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings to rapidly generate complex molecular architectures.
• Fluorine Chemistry Library Synthesis: A key starting material for constructing focused libraries of fluorinated compounds to explore structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	Ethyl 6-Iodo-2-(Trifluoromethyl)Imidazo[1,2-A]Pyridine-3-Carboxylate
CAS No.	900019-79-6
Molecular Formula	C11H6F3IN2O2
Molecular Weight	370.08 g/mol
Synonyms	6-Iodo-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester; Ethyl 6-iodo-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate; 900019-79-6; Imidazo[1,2-a]pyridine-3-carboxylic acid, 6-iodo-2-(trifluoromethyl)-, ethyl ester; Ethyl 6-iodo-2-trifluoromethylimidazo[1,2-a]pyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 6-Iodo-2-(Trifluoromethyl)Imidazo[1,2-A]Pyridine-3-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards of research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.