Description

2-Chloro-5-(Methylsulfonyl)Pyridine is a high-purity, versatile heterocyclic building block and key synthetic intermediate. Its unique structure, featuring both a chloro and a methylsulfonyl substituent on the pyridine ring, makes it a critical precursor for constructing complex molecules in advanced research and development. This compound is essential for pharmaceutical chemists, agrochemical researchers, and material scientists engaged in the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the pyridine core provides key bioactivity.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs) due to its electron-withdrawing sulfonyl group.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, activity-based probes (ABPs), and other tools for studying biological systems.
• Cross-Coupling Reactions: The chloro substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloro-5-(Methylsulfonyl)Pyridine
CAS No.	99903-01-2
Molecular Formula	C6H6ClNO2S
Molecular Weight	191.63 g/mol
Synonyms	2-Chloro-5-methanesulfonylpyridine; 5-(Methylsulfonyl)-2-chloropyridine; 2-Chloropyridine-5-sulfonylmethane; Pyridine, 2-chloro-5-(methylsulfonyl)-; 2-Chloro-5-(methylsulfonyl)pyridine; 2-Chloro-5-methylsulfonylpyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Methylsulfonyl)Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant regulatory frameworks for pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.