Description

Mevastatin Hydroxy Acid Sodium Salt is the bioactive, open-ring form of the pioneering HMG-CoA reductase inhibitor, mevastatin. This compound serves as a critical reference standard and active pharmaceutical ingredient (API) for research and development in lipid metabolism and cardiovascular disease. It is essential for pharmaceutical manufacturers, academic researchers, and contract research organizations (CROs) focused on developing novel statin therapies or studying cholesterol biosynthesis pathways.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of mevastatin and its metabolites in drug development and quality control laboratories.
• Biochemical Research: A key tool for in vitro studies investigating the mechanism of HMG-CoA reductase inhibition and its effects on cellular cholesterol synthesis.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a direct precursor in the synthesis of mevastatin-based formulations for preclinical and clinical studies.
• Metabolic Pathway Analysis: Employed in research to elucidate the pharmacokinetics and pharmacodynamics of statin drugs within biological systems.
• Enzyme Inhibition Assays: Utilized as a specific inhibitor to study the HMG-CoA reductase enzyme complex and screen for potential new lipid-lowering agents.

Basic Information

Product Name	Mevastatin Hydroxy Acid Sodium Salt
CAS No.	99782-89-5
Molecular Formula	C23H35NaO7
Molecular Weight	446.51 g/mol
Synonyms	Mevastatin Sodium Salt; Compactin Hydroxy Acid Sodium Salt; ML-236B Sodium Salt; (3R,5R)-7-[(1S,2S,6S,8S,8aR)-8-Hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid Sodium Salt; Mevastatin Acid Sodium; 6α-Methylcompactin Sodium Salt; Monacolin K Hydroxy Acid Sodium Salt
EINECS	Contact for details

Quality Control

Our Mevastatin Hydroxy Acid Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets stringent specifications for research and pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.