Description

Cholestyramine Resin is a strongly basic anion exchange resin in the chloride form, widely recognized for its ability to bind bile acids in the gastrointestinal tract. This property makes it a critical active pharmaceutical ingredient (API) for managing hypercholesterolemia and relieving pruritus associated with partial biliary obstruction. It is essential for pharmaceutical manufacturers producing cholesterol-lowering medications and for research institutions studying lipid metabolism. The compound, identified by CAS No. 11041-12-6, is supplied as a high-purity, fine powder suitable for formulation.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the treatment of primary hypercholesterolemia.
• Pruritus Relief: Formulated to alleviate severe itching caused by elevated serum bile acids in patients with hepatic disease.
• Research & Development: Used in biochemical and pharmacological research for studying bile acid sequestrants and lipid-lowering mechanisms.
• Excipient & Carrier: Serves as a novel carrier or excipient in controlled-release drug delivery systems due to its ion-exchange capacity.
• Diagnostic Aid: Employed in laboratory procedures for the selective removal or binding of specific anions from biological samples.
• Veterinary Medicine: Incorporated into animal health products for managing lipid disorders in companion and livestock animals.

Basic Information

Product Name	Cholestyramine Resin
CAS No.	11041-12-6
Molecular Formula	(C27H29N·Cl)n (Styrene-divinylbenzene copolymer with quaternary ammonium groups)
Molecular Weight	Polymeric (Not applicable)
Synonyms	Cholestyramine; Colestyramine; MK-325; Questran; Cholestagel; Polidexide; Anion Exchange Resin S-100; Dowex 1; Amberlite IRA-400; Styrene-divinylbenzene quaternary ammonium resin
EINECS	234-270-6

Quality Control

Our Cholestyramine Resin is manufactured and tested to meet stringent pharmacopeial standards, including USP-NF and EP monographs. Each batch undergoes rigorous quality testing to ensure compliance with industry standards for identity, potency, and purity. Certificates of Analysis (COA) documenting key parameters such as exchange capacity, chloride content, and particle size distribution are available upon request. We operate under a cGMP-compliant quality management system to guarantee supply reliability and product consistency for our global pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the resin must be stored in a cool, dry place at a controlled room temperature (15-25°C). The storage area should have low humidity and be free from contaminants. Keep the container tightly sealed immediately after use to prevent moisture absorption, which can affect flow properties and performance.

Specification

Item	Specification
Description	Fine, white to off-white powder
Identification (IR)	Conforms to standard
Assay (Anion Exchange Capacity)	≥ 1.8 mEq/g (dry basis)
Chloride Content	Contact for details
Loss on Drying	≤ 10.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 20 ppm
Particle Size	Contact for details
Microbial Limits	Meets USP <61> and <62>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.