Description

Monacolin M is a bioactive secondary metabolite and a key intermediate in the biosynthesis of monacolin K, a well-known cholesterol-lowering agent. This compound is of significant interest for its role in the research and development of statin-based pharmaceuticals and nutraceuticals. It serves as a critical building block for scientists and manufacturers in the pharmaceutical, biotechnology, and advanced dietary supplement industries seeking to develop or produce cholesterol management products.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthetic or biosynthetic pathways for producing Monacolin K (Lovastatin) and related statin drugs.
• Biochemical Research: Used as a standard or substrate in enzymatic studies to investigate the HMG-CoA reductase pathway and cholesterol biosynthesis.
• Nutraceutical Development: Employed in the formulation and quality control of advanced red yeast rice extracts and other natural cholesterol-lowering supplements.
• Reference Standard: Serves as a high-purity analytical standard for HPLC, LC-MS, or NMR to identify and quantify monacolin compounds in complex matrices.
• Metabolic Engineering: A target molecule in the genetic modification of fungal strains (e.g., *Monascus purpureus*) to optimize the yield of desired monacolins.

Basic Information

Product Name	Monacolin M
CAS No.	106909-04-0
Molecular Formula	C24H36O5
Molecular Weight	404.54 g/mol
Synonyms	Monacolin M; Dihydromonacolin L; (4R,6R)-6-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-2,6-dimethyl-8-[(S)-2-methylbutyryloxy]-1-naphthyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one; 3,4-Dihydromonacolin L; Monacolin M (Dihydromonacolin L); Lovastatin Dihydroxy Acid Precursor
EINECS	Contact for details

Quality Control

Our Monacolin M is produced and tested under a strict quality management system. We provide material suitable for research and development purposes, with specifications typically meeting or exceeding 95% purity (HPLC). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles via validated analytical methods such as HPLC and NMR. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.