Description

Glenvastatin CAS NO 122254-45-9 is a synthetic statin compound, a member of the HMG-CoA reductase inhibitor class. This high-purity active pharmaceutical ingredient (API) is critical for the research and development of novel cholesterol-lowering therapeutics. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers developing innovative cardiovascular drugs.

Application

• Pharmaceutical Research & Development: Serving as a key reference standard and building block in the discovery and synthesis of new statin-based medications.
• Biochemical Studies: Used as a potent inhibitor of HMG-CoA reductase in enzymatic assays and metabolic pathway research.
• Preclinical Development: Essential for pharmacokinetic, pharmacodynamic, and toxicology studies in the development of cardiovascular drugs.
• Analytical Standard: Employed as a high-purity standard for method development, validation, and quality control testing in analytical laboratories.
• Academic Research: Utilized in university and institutional research focused on lipid metabolism, atherosclerosis, and enzyme inhibition mechanisms.

Basic Information

Item	Detail
Product Name	Glenvastatin
CAS No.	122254-45-9
Molecular Formula	C₂₅H₃₄FNO₅
Molecular Weight	447.54 g/mol
Synonyms	Glenvastatin; (3R,5S)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic Acid; GSK 2190915; GSK2190915; 122254-45-9; Glenvastatina; Glenvastatine; Glenvastatinum
EINECS	Contact for details

Quality Control

Our Glenvastatin is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and assay, IR and NMR for structural identification, and rigorous control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.