Description

Simfibrate CAS NO 14929-11-4 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the fibrate class of compounds. It is a critical component in the research and development of lipid-regulating agents, offering significant value in the synthesis of advanced therapeutic formulations. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on cardiovascular and metabolic disease research.

Application

• Pharmaceutical API Synthesis: Primary use as an active pharmaceutical ingredient in the manufacture of lipid-lowering medications.
• Biochemical Research: Used as a reference standard and research tool in studies of peroxisome proliferator-activated receptor (PPAR) activity and lipid metabolism.
• Preclinical Development: Serves as a key intermediate in the development and scale-up of new fibrate-based therapeutic candidates.
• Analytical Standard: Employed as a high-purity standard for quality control and analytical method development (e.g., HPLC, GC) in pharmaceutical analysis.
• Metabolic Disorder Studies: Utilized in in-vitro and in-vivo research models investigating hyperlipidemia, atherosclerosis, and related cardiovascular conditions.

Basic Information

Product Name	Simfibrate
CAS No.	14929-11-4
Molecular Formula	C₂₃H₂₈O₅
Molecular Weight	384.47 g/mol
Synonyms	Simfibrate; 2,2-Bis(4-chlorophenoxy)-2-methylpropionic acid 2-(dimethylamino)ethyl ester; Cholesolvin; CLY-503; Dimethylaminoethyl 2-(4-chlorophenoxy)-2-methylpropionate; 2-(Dimethylamino)ethyl 2-(4-chlorophenoxy)-2-methylpropanoate; 1-Dimethylamino-2-propyl 2-(p-chlorophenoxy)-2-methylpropionate
EINECS	Contact for details

Quality Control

Our Simfibrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profile analysis, to meet stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.