Description

2-(Trifluoromethoxy)Benzenesulfonyl Isocyanate is a specialized, high-purity organic intermediate featuring a reactive isocyanate group and a sulfonyl linker. This compound matters for its role as a critical building block in the synthesis of advanced molecules, enabling the introduction of the unique 2-(trifluoromethoxy)benzenesulfonyl moiety. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonylurea and sulfonamide-based drug candidates, particularly in metabolic disease and oncology research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging the trifluoromethoxy group for enhanced biological activity and environmental stability.
• Polymer Modification: Serves as a functional monomer or cross-linking agent for creating specialty polymers with tailored surface properties and chemical resistance.
• Chemical Biology & Proteomics: Employed as an active-site directed probe or labeling reagent for studying enzyme mechanisms and protein interactions.
• Material Science Research: Facilitates the development of advanced coatings, adhesives, and functional materials requiring specific sulfonyl isocyanate chemistry.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses serving the fine chemical and life science sectors.

Basic Information

Product Name	2-(Trifluoromethoxy)Benzenesulfonyl Isocyanate
CAS No.	99722-81-3
Molecular Formula	C8H4F3NO4S
Molecular Weight	267.18 g/mol
Synonyms	2-(Trifluoromethoxy)benzenesulfonyl isocyanate; 1-Isocyanatosulfonyl-2-(trifluoromethoxy)benzene; α,α,α-Trifluoro-o-anisolesulfonyl isocyanate; o-(Trifluoromethoxy)benzenesulfonyl isocyanate; 2-(Trifluoromethoxy)phenylsulfonyl isocyanate; Benzenesulfonyl isocyanate, 2-(trifluoromethoxy)-; (2-Trifluoromethoxyphenyl)sulfonyl isocyanate
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Benzenesulfonyl Isocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.