Description

Rilmazafone is a synthetic benzodiazepine derivative, recognized for its specific pharmacological profile. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential as a precursor in the synthesis of active pharmaceutical ingredients (APIs). It serves the critical needs of pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of central nervous system (CNS) therapeutics and analytical reference standards.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of specialized benzodiazepine-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a high-purity analytical standard in quality control (QC) and research laboratories for method development and validation.
• Biomedical Research: Employed in preclinical and pharmacological studies to investigate structure-activity relationships (SAR) within the benzodiazepine class.
• Chemical Synthesis: Serves as a building block for medicinal chemists in the development of novel therapeutic compounds targeting the GABA-A receptor.
• Regulatory Compliance: Utilized in the preparation of samples for regulatory submissions and stability testing programs.

Basic Information

Product Name	Rilmazafone
CAS No.	99593-25-6
Molecular Formula	C21H19ClN4O3
Molecular Weight	410.85 g/mol
Synonyms	Rilmazafone; 4-(2-Chlorophenyl)-2-[(4-methyl-1-piperazinyl)methyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-one; 450191-44-3 (Hydrochloride salt); THA-001; Weifa 168; Pro-Dorm
EINECS	Contact for details

Quality Control

Our Rilmazafone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.