Description

4-Azidobutanal is a versatile bifunctional organic compound featuring both an aldehyde and an azide group, making it a valuable click chemistry reagent and synthetic intermediate. Its primary value lies in its ability to participate in Huisgen 1,3-dipolar cycloaddition reactions, enabling efficient and selective conjugation or polymer modification under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, polymer science, and bioconjugation, where it is used to create novel drug-polymer conjugates, functionalized materials, and labeled biomolecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs) and prodrugs via bioorthogonal chemistry.
• Bioconjugation & Labeling: Used to attach fluorescent dyes, peptides, or other functional groups to antibodies, proteins, and oligonucleotides for diagnostics and targeted therapies.
• Polymer & Material Science: Serves as a cross-linking agent or functional monomer for creating hydrogels, smart polymers, and surface-modified nanomaterials with tailored properties.
• Click Chemistry Reagent: A fundamental reagent in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions for modular synthesis.
• Agrochemical Research: Intermediate in the development of new crop protection agents and herbicides with specific modes of action.
• Academic & R&D: Critical tool for chemical biology research, enabling the study of biomolecular interactions and cellular processes.

Basic Information

Product Name	4-Azidobutanal
CAS No.	99545-47-8
Molecular Formula	C4H7N3O
Molecular Weight	113.12 g/mol
Synonyms	4-Azidobutyraldehyde; 4-Azidobutanal; 4-Azidobutan-1-al; Butanal, 4-azido-; Azidobutyraldehyde; ω-Azidobutanal; 4-Azido-1-butanal; 4-Azidobutyl aldehyde
EINECS	Contact for details

Quality Control

Our 4-Azidobutanal is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated). Due to its highly volatile and light-sensitive nature, containers should be kept sealed and allowed to equilibrate to room temperature before opening to minimize moisture ingress and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.