Description

Ethyl 3-Hydroxy-4,4,4-Trifluorobutyrate is a versatile fluorinated organic ester, a key building block in advanced chemical synthesis. Its value lies in the unique combination of a reactive hydroxyl group and a trifluoromethyl moiety, enabling the introduction of fluorine atoms to enhance the properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to develop new active ingredients with improved metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs and anti-inflammatory agents.
• Agrochemical Synthesis: Used to construct fluorinated pyrethroids, herbicides, and fungicides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a starting material for fluorinated liquid crystal compounds and electron-transport materials in organic light-emitting diodes (OLEDs).
• Advanced Polymer Modifiers: Incorporated into specialty polymers to impart unique surface properties, chemical resistance, and altered refractive indices.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and creating novel fluorinated scaffolds.
• Flavor & Fragrance Ingredient Synthesis: Used in the production of certain fluorinated aroma chemicals that exhibit enhanced stability and unique olfactory profiles.

Basic Information

Product Name	Ethyl 3-Hydroxy-4,4,4-Trifluorobutyrate
CAS No.	99437-70-4
Molecular Formula	C6H9F3O3
Molecular Weight	186.13 g/mol
Synonyms	4,4,4-Trifluoro-3-hydroxybutyric Acid Ethyl Ester; 3-Hydroxy-4,4,4-trifluorobutanoic Acid Ethyl Ester; Ethyl 4,4,4-Trifluoro-3-hydroxybutyrate; Ethyl 3-Hydroxy-4,4,4-trifluorobutanoate; 3-Hydroxy-4,4,4-trifluorobutyric Acid Ethyl Ester; TFHB-Et; F3HB-OEt
EINECS	Contact for details

Quality Control

Our Ethyl 3-Hydroxy-4,4,4-Trifluorobutyrate is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with full traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly closed to minimize moisture absorption from the air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.380 - 1.390
Density (20°C)	1.25 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.