Description

Pyrrolidine, 1-(2-Fluoro-3-Hydroxy-4,4-Dimethyl-1-Oxopentyl)-, (R*,R*)- (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, where its defined stereocenters and fluorinated moiety are essential for achieving desired biological activity and metabolic stability.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the production of complex, stereochemically-defined active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new drug candidates, leveraging its fluorinated and hydroxy-substituted structure.
• Process Chemistry: Employed in scale-up and route development for the commercial manufacturing of target molecules.
• Synthesis of Fluorinated Compounds: The fluorine atom makes it a valuable precursor for creating compounds with enhanced bioavailability, metabolic stability, and binding affinity.
• Chiral Auxiliary or Ligand Precursor: Its defined (R*,R*) stereochemistry can be exploited in asymmetric synthesis to induce chirality in other molecules.

Basic Information

Item	Details
Product Name	Pyrrolidine, 1-(2-Fluoro-3-Hydroxy-4,4-Dimethyl-1-Oxopentyl)-, (R*,R*)- (9Ci)
CAS No.	99343-20-1
Molecular Formula	C11H20FNO3
Molecular Weight	233.28 g/mol
Synonyms	1-(2-Fluoro-3-hydroxy-4,4-dimethyl-1-oxopentyl)pyrrolidine; (R*,R*)-1-(2-Fluoro-3-hydroxy-4,4-dimethyl-1-oxopentyl)pyrrolidine; 2-Fluoro-3-hydroxy-4,4-dimethyl-1-pyrrolidin-1-ylpentan-1-one; 99343-20-1; Fluorinated pyrrolidine derivative; Hydroxy ketone pyrrolidine intermediate; Stereoisomeric fluorohydroxy ketone
EINECS	Contact for details

Quality Control

Every batch of Pyrrolidine, 1-(2-Fluoro-3-Hydroxy-4,4-Dimethyl-1-Oxopentyl)-, (R*,R*)- (9Ci) is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and isomeric purity suitable for demanding pharmaceutical applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.