Description

(S)-7-Amino-6,7-Dihydro-9H-5-Oxa-9-Aza-Benzocyclohepten-8-One Hydrochloride is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key building block for the development of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel, patent-protected drugs.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of novel, enantiomerically pure active pharmaceutical ingredients (APIs).
• CNS Drug Development: Used in research and production pathways for potential therapeutics targeting neurological and psychiatric disorders.
• Asymmetric Synthesis: Serves as a key starting material or intermediate in catalytic asymmetric reactions to construct complex molecular architectures.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and commercial-scale manufacturing of advanced drug candidates.
• Reference Standard: Utilized as a high-purity analytical standard for method development, validation, and quality control in API production.
• Academic & Industrial Research: Facilitates medicinal chemistry programs and structure-activity relationship (SAR) studies in both academic and industrial R&D settings.

Basic Information

Product Name	(S)-7-Amino-6,7-Dihydro-9H-5-Oxa-9-Aza-Benzocyclohepten-8-One Hydrochloride
CAS No.	99197-91-8
Molecular Formula	C10H11N2O2•HCl
Molecular Weight	226.67 g/mol
Synonyms	(S)-7-Amino-6,7-dihydro-5H-[1,4]oxazino[3,2,1-ij]quinolin-5-one hydrochloride; (S)-7-Amino-6,7-dihydro-5H-[1,4]oxazino[3,2,1-ij]quinoline-5-one hydrochloride; (S)-7-Amino-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one HCl; (S)-7-Amino-5-oxa-9-aza-benzocyclohepten-8-one hydrochloride; (S)-Aminodihydrooxazinoquinolinone hydrochloride; (S)-ADOO hydrochloride; (S)-enantiomer of 7-Amino-6,7-dihydro-5H-[1,4]oxazino[3,2,1-ij]quinolin-5-one HCl
EINECS	Contact for details

Quality Control

Our production of (S)-7-Amino-6,7-Dihydro-9H-5-Oxa-9-Aza-Benzocyclohepten-8-One Hydrochloride adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98.0% by HPLC), chiral purity (≥99.0% ee), and impurity profiles. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.