Description

Ethyl 2,3,4,6-Tetra-o-Acetyl-1-Thio-D-Mannopyranoside (Min. 85% α-Anomer) is a key thioglycoside building block and glycosyl donor extensively used in carbohydrate and glycoconjugate synthesis. Its value lies in providing a protected mannose derivative with a reactive anomeric thioethyl group, enabling stereoselective glycosylation reactions critical for producing complex oligosaccharides. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel glycotherapeutics, vaccines, and diagnostic agents. The product is supplied with a guaranteed minimum of 85% α-anomer content, ensuring consistent reactivity and yield for demanding synthetic applications.

Application

• Glycosylation Reagent: Serves as a versatile mannosyl donor in the stereoselective synthesis of α-linked oligosaccharides and glycoconjugates.
• Pharmaceutical Intermediate: A critical building block for the research and development of carbohydrate-based drugs, including antiviral and anticancer agents.
• Glycobiology Research: Used to prepare defined oligosaccharide probes, standards, and substrates for studying carbohydrate-protein interactions and enzymatic activity.
• Vaccine Adjuvant Development: Employed in the synthesis of synthetic carbohydrate antigens and immunostimulatory molecules for conjugate vaccine platforms.
• Glycopolymer Synthesis: Acts as a monomer or initiator for creating synthetic polymers with pendant sugar moieties for material science and biomedical applications.
• Enzyme Inhibitor Synthesis: A precursor for developing glycosidase and glycosyltransferase inhibitors with therapeutic potential.

Basic Information

Product Name	Ethyl 2,3,4,6-Tetra-o-Acetyl-1-Thio-D-Mannopyranoside (Min. 85% α-Anomer)
CAS No.	99031-86-4
Molecular Formula	C16H24O9S
Molecular Weight	392.42 g/mol
Synonyms	Ethyl 1-Thio-α-D-mannopyranoside Tetraacetate; 1-Thioethyl-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside; Ethyl 2,3,4,6-Tetra-O-acetyl-1-thio-α-D-mannopyranoside; α-D-Mannopyranoside, ethyl 2,3,4,6-tetra-O-acetyl-1-thio-; Ethyl Tetra-O-acetyl-1-thio-α-D-mannopyranoside; SEtMan(Ac)4-α; ETM-Ac4-α
EINECS	Contact for details

Quality Control

Our Ethyl 2,3,4,6-Tetra-o-Acetyl-1-Thio-D-Mannopyranoside is manufactured under strict quality control protocols to ensure high chemical purity and anomeric consistency. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC and NMR, to confirm identity, anomeric ratio (≥85% α-anomer), and impurity profiles. Certificates of Analysis (COA) detailing all relevant specifications are provided to guarantee material suitability for sensitive research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
α-Anomer Content (HPLC)	≥ 85.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.