Description

Imiquimod (Hydrochloride) is a synthetic, small-molecule immune response modifier belonging to the imidazoquinoline family. This compound is of significant commercial and therapeutic importance due to its potent activity as a toll-like receptor 7 (TLR7) agonist, which stimulates the innate immune system. It is primarily required by the pharmaceutical industry for the formulation of topical medications used in dermatology and oncology. The high-purity grade of this active pharmaceutical ingredient (API) is essential for ensuring the efficacy and safety of the final drug product.

Application

• Topical Cream Formulations: Primary active ingredient in prescription medications for the treatment of external genital and perianal warts (condyloma acuminata).
• Actinic Keratosis Therapy: Used in topical treatments for pre-cancerous skin lesions caused by sun damage.
• Superficial Basal Cell Carcinoma (sBCC): A non-surgical treatment option for certain types of early-stage skin cancer.
• Immunological Research: A key reference standard and tool compound in preclinical research for studying TLR7-mediated immune pathways.
• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of more complex immunomodulatory agents.
• Veterinary Dermatology: Investigated for use in topical treatments for certain skin conditions in animals.

Basic Information

Product Name	Imiquimod (Hydrochloride)
CAS No.	99011-78-6
Molecular Formula	C14H17ClN4·HCl
Molecular Weight	317.22 g/mol
Synonyms	1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride; Imiquimod HCl; R-837 hydrochloride; Aldara (brand name) API; S-26308; TLR7 Agonist R-837 hydrochloride; 4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline hydrochloride
EINECS	Contact for details

Quality Control

Our Imiquimod (Hydrochloride) is manufactured under strict quality management systems. It is produced to meet high-purity standards suitable for pharmaceutical applications, with typical purity levels exceeding 99.0% (by HPLC). Each batch undergoes rigorous analytical testing including identification, assay, impurity profiling, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all test results against predefined specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.2%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.