Description

5-(3',4'-Dihydroxybutyl)-2-Pyridinecarboxylic Acid is a high-purity, functionalized pyridine derivative of significant interest in advanced organic synthesis. This compound matters as a versatile chiral building block and key intermediate for the development of complex pharmaceutical molecules and fine chemicals. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in neurological and metabolic disorder research.
• Ligand Precursor: Used in the preparation of specialized ligands for asymmetric catalysis and metal complexation.
• Fine Chemical Synthesis: Serves as a building block for creating complex molecules with specific stereochemistry in agrochemicals and performance materials.
• Bioconjugation Chemistry: The carboxylic acid and diol functionalities enable its use in linker chemistry for antibody-drug conjugates (ADCs) and other bioconjugates.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Chemical Biology Probes: Useful for designing molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	5-(3',4'-Dihydroxybutyl)-2-Pyridinecarboxylic Acid
CAS No.	98985-54-7
Molecular Formula	C11H15NO5
Molecular Weight	241.24 g/mol
Synonyms	2-Pyridinecarboxylic acid, 5-(3,4-dihydroxybutyl)-; 5-(3,4-Dihydroxybutyl)picolinic acid; (5-(3,4-Dihydroxybutyl)pyridin-2-yl)methanol (oxidized form); Picolinic acid, 5-(3,4-dihydroxybutyl)-; DHB-Pyridine-2-carboxylic Acid; 98985-54-7; 5-(3,4-Dihydroxybutyl)-2-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(3',4'-Dihydroxybutyl)-2-Pyridinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.