Description

n-Methyl-3-(Trimethylsilyl)-2-Propynamide is a specialized organosilicon building block featuring both a silyl-protected alkyne and an amide functional group. This unique bifunctional structure makes it a valuable intermediate for constructing complex molecules in advanced synthetic chemistry. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the synthesis of novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing alkyne handles for click chemistry or further functionalization.
• Agrochemical Synthesis: Used in the research and development of novel pesticides, herbicides, and plant growth regulators requiring specific silicon-containing motifs.
• Material Science Research: Serves as a precursor for developing advanced polymers, dendrimers, or silicon-based hybrid materials with tailored properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the creation of compound libraries for drug discovery programs.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne can be deprotected to generate terminal alkynes for Sonogashira and other palladium-catalyzed coupling reactions.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or probes for studying biological processes.

Basic Information

Product Name	n-Methyl-3-(Trimethylsilyl)-2-Propynamide
CAS No.	98876-06-3
Molecular Formula	C8H15NOSi
Molecular Weight	169.30 g/mol
Synonyms	N-Methyl-3-(trimethylsilyl)propiolamide; 3-(Trimethylsilyl)-N-methylpropiolamide; N-Methyl-3-(trimethylsilyl)prop-2-ynamide; Propiolamide, N-methyl-3-(trimethylsilyl)-; TMS-Propargylamide, N-Methyl; Methyl(trimethylsilyl)propiolamide
EINECS	Contact for details

Quality Control

Our n-Methyl-3-(Trimethylsilyl)-2-Propynamide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and GC analysis. Certificates of Analysis (COA) detailing purity and identity are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.