Description

Mafosfamide-Lysine CAS NO 98845-64-8 is a chemically modified prodrug of the active metabolite of ifosfamide, designed to enhance stability and targeted delivery. This compound is of significant interest in advanced pharmaceutical research, particularly for its potential in developing novel chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical developers, and contract manufacturing organizations (CMOs) engaged in oncology drug discovery and preclinical development.

Application

• Oncology Research: Serves as a key intermediate or reference standard in the development of novel alkylating agent-based chemotherapies.
• Prodrug Development: Used in studies focusing on improving the pharmacokinetic profile and reducing the systemic toxicity of parent drugs like ifosfamide.
• Biochemical Research: Employed as a tool compound to investigate mechanisms of action related to DNA cross-linking and apoptosis in cancer cell lines.
• Pharmaceutical Synthesis: Acts as a critical building block in the synthetic pathways for specialized anticancer agents.
• Analytical Reference: Provides a high-purity standard for quality control and method validation in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	Mafosfamide-Lysine
CAS No.	98845-64-8
Molecular Formula	C14H26Cl2N4O6P
Molecular Weight	457.26 g/mol
Synonyms	Lysine Salt of Mafosfamide; NSC-345842; 4-Hydroperoxy-Ifosfamide Lysine Salt; Ifosfamide 4-Hydroperoxide Lysine Salt; (2S)-6-Amino-2-[[[2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphosphinan-4-yl]oxy]carbonylamino]hexanoic acid 2-oxide; ZIO-201 (Lysine Salt); Asta Z 4942 Lysine Salt
EINECS	Contact for details

Quality Control

Our Mafosfamide-Lysine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.