Description

5-Bromo-2-Methanesulfonyl-Pyridine is a high-purity, versatile heterocyclic building block of significant importance in advanced organic synthesis. This compound is valued for its dual functional groups—a bromine substituent and a methanesulfonyl group—which enable precise and diverse chemical transformations. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Material Science Research: Serves as a precursor for creating functionalized pyridine derivatives used in ligands for catalysis or in advanced polymeric materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl structures.
• Sulfonyl Group Manipulation: The methanesulfonyl moiety can act as a good leaving group or be modified, providing a handle for further functionalization in multi-step syntheses.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and target engagement.

Basic Information

Product Name	5-Bromo-2-Methanesulfonyl-Pyridine
CAS No.	98626-95-0
Molecular Formula	C7H8BrNO2S
Molecular Weight	250.11 g/mol
Synonyms	2-Bromo-5-(methylsulfonyl)pyridine; 5-Bromo-2-(methylsulfonyl)pyridine; 2-Pyridinesulfonic acid, 5-bromo-, methyl ester; 98626-95-0; 5-Bromo-2-methanesulfonylpyridine; 5-Bromo-2-methylsulfonylpyridine; Methyl 5-bromo-2-pyridinesulfonate
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Methanesulfonyl-Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.