Description

3-Iodo-Cyclobutanecarboxylic Acid Ethyl Ester is a versatile iodinated cyclobutane derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its unique structural motif, which is highly valuable for constructing complex, strained-ring systems and for introducing iodine as a functional handle for further cross-coupling reactions. Pharmaceutical, agrochemical, and material science researchers need this high-purity intermediate to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly those containing strained carbocyclic or iodine-substituted structures.
• Agrochemical Research: Used in the synthesis of new herbicides, fungicides, and insecticides that leverage the cyclobutane ring for unique biological activity.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals where the cyclobutane core influences material properties.
• Cross-Coupling Reactions: The iodine atom acts as an excellent leaving group in palladium-catalyzed reactions (e.g., Suzuki, Negishi, Stille) for carbon-carbon bond formation.
• Chemical Biology Probes: Utilized in the creation of molecular probes and tags for studying biological systems, benefiting from the iodine's potential for radiolabeling or further functionalization.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for exploring new chemical space in high-throughput screening libraries.

Basic Information

Product Name	3-Iodo-Cyclobutanecarboxylic Acid Ethyl Ester
CAS No.	98431-45-9
Molecular Formula	C7H11IO2
Molecular Weight	254.07 g/mol
Synonyms	Ethyl 3-Iodocyclobutanecarboxylate; 3-Iodocyclobutanecarboxylic Acid Ethyl Ester; Cyclobutanecarboxylic acid, 3-iodo-, ethyl ester; Ethyl 3-iodocyclobutane-1-carboxylate; 98431-45-9; AI3-52495; SCHEMBL218269; ZINC000253949996; AKOS015915623
EINECS	Contact for details

Quality Control

Our 3-Iodo-Cyclobutanecarboxylic Acid Ethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.