Description

trans-3-(tert-Butyldimethylsilyloxy)-1-Methoxy-1,3-Butadiene is a high-value, protected diene intermediate essential for complex organic synthesis. Its core value lies in its role as a versatile building block for constructing intricate molecular frameworks, particularly in the synthesis of natural products and pharmaceuticals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those containing diene or polyene structures.
• Diels-Alder Reactions: Serves as a reactive diene component in cycloaddition reactions to construct six-membered carbocyclic and heterocyclic rings.
• Natural Product Synthesis: Used in the total synthesis of terpenoids, polyketides, and other natural products requiring stereoselective introduction of functionalized diene units.
• Agrochemical Research: Employed in the development of novel active ingredients where specific diene chemistry is required.
• Material Science: Potential monomer or precursor for specialized polymers and advanced organic materials.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory chemistry in university and CRO laboratories.

Basic Information

Product Name	trans-3-(tert-Butyldimethylsilyloxy)-1-Methoxy-1,3-Butadiene
CAS No.	98066-22-9
Molecular Formula	C11H22O2Si
Molecular Weight	214.38 g/mol
Synonyms	1-Methoxy-3-[(1,1-dimethylethyl)dimethylsilyl]oxy-1,3-butadiene; (E)-1-Methoxy-3-[(tert-butyldimethylsilyl)oxy]-1,3-butadiene; Danishefsky's Diene (TBS-protected); TBS-Danishefsky Diene; trans-1-Methoxy-3-(tert-butyldimethylsilyloxy)-1,3-butadiene; 3-(tert-Butyldimethylsiloxy)-1-methoxy-1,3-butadiene; (E)-1-Methoxy-3-((tert-butyldimethylsilyl)oxy)-1,3-butadiene
EINECS	Contact for details

Quality Control

Our trans-3-(tert-Butyldimethylsilyloxy)-1-Methoxy-1,3-Butadiene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. Due to its highly volatile and easily oxidized nature, the container should be kept tightly sealed and allowed to equilibrate to room temperature before opening to minimize moisture ingress and degradation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Isomeric Purity (trans)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.