Description

1,3-Dioxolane-4-Carbothioic Acid, 2-(1,1-Dimethylethyl)-4-(1-Hydroxy-1-Methylethyl)-, S-(1,1-Dimethylethyl) Ester, (2R-Trans)- is a high-purity, stereochemically defined advanced intermediate. This compound is valued for its role in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for constructing novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in exploratory and preclinical development stages.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to introduce specific three-dimensional configurations into target molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in drug discovery programs to explore structure-activity relationships (SAR).
• Process Chemistry Development: Used in the optimization and scale-up of synthetic routes for potential drug candidates.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, agrochemicals, and other high-value materials requiring precise stereochemistry.

Basic Information

Item	Detail
Product Name	1,3-Dioxolane-4-Carbothioic Acid, 2-(1,1-Dimethylethyl)-4-(1-Hydroxy-1-Methylethyl)-, S-(1,1-Dimethylethyl) Ester, (2R-Trans)-
CAS No.	98041-28-2
Molecular Formula	C14H26O4S
Molecular Weight	290.42 g/mol
Synonyms	(2R-trans)-2-tert-Butyl-4-(2-hydroxy-2-propyl)-1,3-dioxolane-4-carbothioic acid S-tert-butyl ester; S-tert-Butyl (2R,4R)-2-tert-butyl-4-(2-hydroxypropan-2-yl)-1,3-dioxolane-4-carbothioate; tert-Butyl (2R,4R)-2-tert-butyl-4-(1-hydroxy-1-methylethyl)-1,3-dioxolane-4-carbothioate; (2R,4R)-2-tert-Butyl-4-(1-hydroxy-1-methylethyl)-1,3-dioxolane-4-carbothioic acid S-tert-butyl ester; 98041-28-2; (2R,4R)-Dioxolane carbothioate intermediate
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane-4-Carbothioic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.