Description

6-Azidoketanserin is a specialized azido-functionalized derivative of the serotonin 5-HT2A receptor antagonist ketanserin. This compound is a critical intermediate and research tool in the development of novel pharmacological probes and photoaffinity labeling agents for studying serotonin receptor structure and function. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotech companies engaged in neuropharmacology, receptor biochemistry, and medicinal chemistry.

Application

• Photoaffinity Labeling: Acts as a key precursor for synthesizing photoaffinity probes to covalently label and map the binding sites of 5-HT2A receptors.
• Medicinal Chemistry Research: Serves as a versatile building block for the synthesis of novel analogs and potential drug candidates targeting serotonin pathways.
• Biochemical Tool Development: Used to create tagged or conjugated ligands for receptor isolation, purification, and characterization studies.
• Neuropharmacology Studies: Employed in research to investigate the structure-activity relationships (SAR) of serotonergic compounds.
• High-Throughput Screening (HTS): Can be utilized in the development of assays to identify new modulators of serotonin receptor activity.

Basic Information

Product Name	6-Azidoketanserin
CAS No.	97930-92-2
Molecular Formula	C22H22FN5O2
Molecular Weight	407.45 g/mol
Synonyms	6-Azido-ketanserin; 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2-azido-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; Azidoketanserin; 6-N3-Ketanserin; Ketanserin azide derivative
EINECS	Contact for details

Quality Control

Our 6-Azidoketanserin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.