Description

(S)-(-)-α-(1-Naphthyl)-Ethylisocyanide is a high-value chiral isocyanide building block, essential for the synthesis of complex organic molecules. Its unique stereochemistry and functional group make it a critical reagent for constructing chiral centers in pharmaceuticals and advanced materials. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• As a chiral ligand precursor in transition metal-catalyzed asymmetric reactions.
• Key building block for the synthesis of chiral heterocycles and natural product analogs.
• Utilized in the development of novel pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• Employed in the preparation of chiral catalysts for enantioselective synthesis.
• Research reagent for exploring new methodologies in isocyanide-based multicomponent reactions (e.g., Passerini, Ugi).
• Starting material for the synthesis of chiral isonitriles used in coordination chemistry and material science.

Basic Information

Product Name	(S)-(-)-α-(1-Naphthyl)-Ethylisocyanide
CAS No.	97903-88-3
Molecular Formula	C₁₃H₁₁N
Molecular Weight	181.24 g/mol
Synonyms	(S)-1-(1-Naphthyl)ethyl isocyanide; (S)-(-)-1-(1-Naphthyl)ethyl isocyanide; (S)-1-(Naphthalen-1-yl)ethyl isocyanide; (S)-α-Methyl-1-naphthaleneacetonitrile N-oxide (tautomer); (S)-(-)-α-(1-Naphthyl)ethyl isocyanide; (S)-1-(1-Naphthyl)ethyl isonitrile; (S)-(-)-1-(1-Naphthyl)ethyl isonitrile
EINECS	Contact for details

Quality Control

Our (S)-(-)-α-(1-Naphthyl)-Ethylisocyanide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency. Each lot is characterized by advanced analytical techniques including chiral HPLC, NMR, and GC-MS to confirm identity, enantiomeric excess, and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.