Description

5-Bromo-2-Pyridinecarbonitrile is a versatile brominated pyridine derivative that serves as a crucial synthetic intermediate in advanced organic chemistry. Its value lies in the strategic positioning of the bromine and nitrile functional groups, which enable efficient cross-coupling reactions and further functionalization. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials and liquid crystals.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Nitrile Transformation: The cyano group can be hydrolyzed to carboxylic acids, reduced to amines, or used to form heterocycles like tetrazoles.

Basic Information

Product Name	5-Bromo-2-Pyridinecarbonitrile
CAS No.	97483-77-7
Molecular Formula	C6H3BrN2
Molecular Weight	183.01 g/mol
Synonyms	5-Bromopicolinonitrile; 2-Cyano-5-bromopyridine; 5-Bromo-2-cyanopyridine; 5-Bromopyridine-2-carbonitrile; 5-Bromo-2-pyridyl cyanide; 97483-77-7; 5-Bromo-2-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Pyridinecarbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality assurance, with products typically meeting a purity specification of ≥97% (by HPLC). A detailed Certificate of Analysis (COA) is supplied with each batch, documenting identity, purity, and impurity profiles. Our quality control protocols are designed to support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.