Description

Proline, 5-Ethyl-, Methyl Ester, cis- (9Ci) is a specialized proline derivative, a non-proteinogenic amino acid ester with a defined cis-configuration. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, valued for its ability to introduce conformational constraints and stereochemical complexity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for protease inhibitors and other biologically active molecules.
• Peptidomimetics & Constrained Peptide Design: Used to synthesize modified peptides where the ethyl and ester groups introduce specific steric and electronic properties, enhancing metabolic stability and binding affinity.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective reactions to construct complex molecular architectures.
• Agrochemical Research: Employed in the synthesis of novel, biologically active compounds for crop protection and plant science applications.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Proline, 5-Ethyl-, Methyl Ester, cis- (9Ci)
CAS No.	97465-31-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	cis-5-Ethyl-L-proline methyl ester; Methyl cis-5-ethylprolinate; (2S,5S)-5-Ethylpyrrolidine-2-carboxylic acid methyl ester; L-Proline, 5-ethyl-, methyl ester, cis-; 5-Ethylproline methyl ester; Proline derivative CAS 97465-31-1; (S,S)-5-Ethylproline methyl ester
EINECS	Contact for details

Quality Control

We supply Proline, 5-Ethyl-, Methyl Ester, cis- (9Ci) to high-purity standards suitable for research and development applications. Every batch is characterized and tested to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from analytical methods including HPLC, NMR, and chiral analysis. Our quality system supports compliance with cGMP and ISO standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98.0% de (cis-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.