Description

Piperidine, 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]- is a specialized organosilicon-protected piperidine derivative, serving as a crucial synthetic intermediate and protecting group reagent in advanced organic synthesis. Its primary value lies in enabling complex multi-step syntheses by providing a stable, silyl-protected amino alcohol functionality that can be selectively deprotected under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity building blocks for developing active pharmaceutical ingredients (APIs), novel ligands, and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of piperidine-based drug candidates, including receptor modulators and enzyme inhibitors.
• Chiral Auxiliary/Synthon: Used in asymmetric synthesis to introduce stereocenters, particularly in the construction of complex alkaloids and bioactive molecules.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group protects the hydroxyl function during multi-step synthetic sequences, allowing for orthogonal deprotection strategies.
• Ligand Synthesis: Precursor for nitrogen-oxygen (N,O) bidentate ligands used in catalysis, such as for transition metal complexes.
• Agrochemical Research: Intermediate in the development of new crop protection agents and herbicides with piperidine scaffolds.
• Material Science: Used in the synthesis of functionalized monomers or additives for specialty polymers.

Basic Information

Item	Detail
Product Name	Piperidine, 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-
CAS No.	97231-91-9
Molecular Formula	C11H25NOSi
Molecular Weight	215.41 g/mol
Synonyms	4-[(tert-Butyldimethylsilyl)oxy]piperidine; 4-(TBDMS-oxy)piperidine; 4-(tert-Butyldimethylsiloxy)piperidine; 4-Hydroxypiperidine TBDMS ether; N-Azaspiro[2.5]octane-5-methanol, 1-tert-butyldimethylsilyl ether (related structure); 4-OTBDMS-piperidine; 4-Piperidinol, 1-(1,1-dimethylethyl)dimethylsilyl ether
EINECS	Contact for details

Quality Control

Our Piperidine, 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.