Description

3',5'-o-(Di-tert-Butylsilanediyl)Uridine is a protected nucleoside derivative where the 3' and 5' hydroxyl groups of uridine are shielded by a di-tert-butylsilylene group. This compound is a crucial synthetic intermediate in the preparation of modified oligonucleotides, enabling precise control over RNA structure and function. It is primarily utilized by research institutions and pharmaceutical companies engaged in antisense drug development, siRNA therapeutics, and advanced nucleotide chemistry.

Application

• Oligonucleotide Synthesis: Key building block for the solid-phase synthesis of modified RNA strands, particularly where 2'-O-alkylation or other modifications are required.
• Antisense & siRNA Therapeutics: Serves as a protected intermediate in the production of research-grade and therapeutic oligonucleotides targeting specific gene sequences.
• Medicinal Chemistry Research: Used in the discovery and development of novel nucleoside-based antiviral and anticancer agents.
• Bioconjugation & Probe Development: Facilitates the site-specific labeling of RNA molecules with fluorophores or other reporter groups for diagnostic applications.
• Process Chemistry: Employed in the scalable manufacturing of active pharmaceutical ingredients (APIs) for nucleic acid-based drugs.

Basic Information

Product Name	3',5'-o-(Di-tert-Butylsilanediyl)Uridine
CAS No.	97219-04-0
Molecular Formula	C17H30N2O6Si
Molecular Weight	386.52 g/mol
Synonyms	Uridine, 3',5'-(1,1-dimethylethyl)silanediyl)bis-; 3',5'-Di-O-(tert-butyldimethylsilyl)uridine (common error/related compound); 3',5'-O-(Di-tert-butylsilanediyl)uridine; 1-((2R,3R,4S,5R)-3,4-Bis((tert-butyldimethylsilyl)oxy)-5-((tert-butyldimethylsilyloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (related IUPAC); DMTBS-Uridine; DTBS-Uridine; Protected Uridine; Nucleoside Silyl Ether
EINECS	Contact for details

Quality Control

Our 3',5'-o-(Di-tert-Butylsilanediyl)Uridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for water content. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.