Description

tert-Butyloxycarbonyl-Phenylalanyl-Phenylalanyl-Glycine Hydroxylamine is a specialized, protected tripeptide derivative designed for advanced peptide synthesis and biochemical research. This compound serves as a critical building block for constructing complex peptide sequences, offering precise control over molecular architecture. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers focused on developing novel therapeutic agents and biochemical probes. Its unique structure facilitates the introduction of specific amino acid sequences under controlled conditions.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and for investigating protease mechanisms and protein-protein interactions.
• Peptide Library Construction: Essential for combinatorial chemistry and high-throughput screening to discover new bioactive peptides.
• Protease Inhibitor Development: Serves as a core structure for designing and testing selective inhibitors for various proteolytic enzymes.
• Conjugation Chemistry: The hydroxylamine and Boc-protected groups allow for specific bioconjugation and linker attachment in bioconjugate and ADC (Antibody-Drug Conjugate) development.
• Academic & Industrial R&D: Employed in fundamental research to study peptide folding, stability, and structure-activity relationships (SAR).

Basic Information

Product Name	tert-Butyloxycarbonyl-Phenylalanyl-Phenylalanyl-Glycine Hydroxylamine
CAS No.	97207-35-7
Molecular Formula	C25H31N3O6
Molecular Weight	469.53 g/mol
Synonyms	Boc-Phe-Phe-Gly-NHOH; Boc-L-Phe-L-Phe-Gly-hydroxylamine; N-(tert-Butoxycarbonyl)-L-phenylalanyl-L-phenylalanylglycine hydroxylamine; (2S)-2-[[(2S)-2-[(2-[(tert-Butoxycarbonyl)amino]-1-oxo-3-phenylpropyl]amino]-1-oxo-3-phenylpropyl]amino]acetic acid, N-hydroxyamide; Boc-Phe-Phe-Gly-NH2OH; tert-Butyl N-[(2S)-1-[[(2S)-1-[(1-hydroxyamino)-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyloxycarbonyl-Phenylalanyl-Phenylalanyl-Glycine Hydroxylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral purity analysis to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.