Description

(R)-12-Methyloxacyclododecane-2,5-Dione CAS NO 97143-17-4 is a high-purity chiral lactone building block of significant interest in advanced organic synthesis. Its defined stereochemistry and functionalized macrocyclic structure make it a valuable precursor for the development of complex molecules with specific biological activities. This compound is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for applications in asymmetric synthesis, medicinal chemistry, and the creation of novel fragrance components.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in macrolide and polyketide-based drug discovery programs.
• Asymmetric Catalyst Ligand Precursor: Used in the synthesis of sophisticated chiral ligands and organocatalysts for enantioselective transformations.
• Fine Chemical Synthesis: Serves as a building block for the production of specialty chemicals, including complex natural product analogs and high-value aroma chemicals.
• Academic & Industrial Research: Employed in methodological studies and the synthesis of structurally complex molecules for biological evaluation and material science.
• Fragrance & Flavor Chemistry: Acts as a precursor for the synthesis of macrocyclic musk analogs and other specialty odorants with unique olfactory profiles.

Basic Information

Product Name	(R)-12-Methyloxacyclododecane-2,5-Dione
CAS No.	97143-17-4
Molecular Formula	C₁₂H₂₀O₃
Molecular Weight	212.29 g/mol
Synonyms	(R)-12-Methyloxacyclododecane-2,5-dione; (R)-(-)-12-Methyloxacyclododecane-2,5-dione; (3R,6S)-3,6-Dimethyl-1,4-dioxacyclododecane-2,5-dione; (R)-3,6-Dimethyl-1,4-dioxacyclododecan-2,5-dione; (R)-Macrolide intermediate; (R)-12-Methyl-1-oxacyclododecane-2,5-dione; (R)-Lactone derivative CAS 97143-17-4
EINECS	Contact for details

Quality Control

Our (R)-12-Methyloxacyclododecane-2,5-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, identity confirmation by IR and NMR spectroscopy, and quantification of key impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.