Description

3-Bromo-2-Ethynylpyridine is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a bromine substituent and an ethynyl group, makes it an invaluable precursor for constructing complex molecular architectures through cross-coupling and cycloaddition reactions. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of new generation herbicides, fungicides, and plant growth regulators requiring pyridine-based scaffolds.
• Material Science Precursor: Employed in the creation of conjugated polymers, ligands for metal-organic frameworks (MOFs), and other advanced organic electronic materials.
• Cross-Coupling Reactions: Serves as a substrate in Sonogashira, Suzuki-Miyaura, and Buchwald-Hartwig amination reactions to introduce the 2-ethynylpyridine moiety.
• Click Chemistry: The terminal alkyne group is reactive in copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer functionalization.
• Ligand Synthesis: Used to prepare novel nitrogen-donor ligands for catalysis and coordination chemistry.

Basic Information

Product Name	3-Bromo-2-Ethynylpyridine
CAS No.	96439-99-5
Molecular Formula	C7H4BrN
Molecular Weight	182.02 g/mol
Synonyms	2-Ethynyl-3-bromopyridine; 3-Bromo-2-ethynyl-pyridine; 3-Bromo-2-pyridylacetylene; 2-(3-Bromopyridin-2-yl)ethyne; Pyridine, 3-bromo-2-ethynyl-; 3-Bromo-2-ethinylpyridin; 3-Bromo-2-ethinylpyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Ethynylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to light and oxidation, prolonged exposure to air and light should be avoided. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC-MS)	Conforms to reference standard
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥96.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.