Description

L-Glutamine, N,N2-Bis(tert-Butyldimethylsilyl)-, tert-Butyldimethylsil Yl Ester is a highly protected derivative of the amino acid L-glutamine, designed for advanced synthetic applications where selective deprotection is required. This compound matters for its role as a crucial synthetic intermediate, offering chemists precise control over reactivity in complex multi-step organic syntheses. It is primarily needed by research chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of peptides, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a protected glutamine residue, preventing unwanted side reactions.
• Protecting Group Strategy: Serves as a reagent in synthetic methodologies where the tert-butyldimethylsilyl (TBDMS) groups are used for temporary protection of amine functionalities.
• Bioconjugation & Probe Development: Employed in the preparation of modified amino acids for creating labeled peptides or chemical probes used in biochemical research.
• Process Chemistry & Scale-up: Utilized in the development and optimization of scalable synthetic routes for target molecules in kilo-lab and pilot plant settings.

Basic Information

Product Name	L-Glutamine, N,N2-Bis(tert-Butyldimethylsilyl)-, tert-Butyldimethylsil Yl Ester
CAS No.	96381-42-9
Molecular Formula	C₂₁H₄₇NO₃Si₃
Molecular Weight	461.88 g/mol
Synonyms	N,N-Bis(tert-butyldimethylsilyl)-L-glutamine tert-butyldimethylsilyl ester; L-Glutamine, N2,N-bis[(1,1-dimethylethyl)dimethylsilyl]-, 1-[(1,1-dimethylethyl)dimethylsilyl] ester; (S)-2,5-Bis((tert-butyldimethylsilyl)amino)-5-oxopentyl tert-butyldimethylsilane; TBDMS-Gln-OTBDMS; Fully protected L-glutamine TBDMS derivative; Nα,Nε-Bis-TBDMS-L-glutamine O-TBDMS ester
EINECS	Contact for details

Quality Control

Our L-Glutamine, N,N2-Bis(tert-Butyldimethylsilyl)-, tert-Butyldimethylsil Yl Ester is produced and tested under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, purity (by HPLC/NMR), and chiral purity. We support compliance with relevant guidelines for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.