Description

(E)-3-(Dimethylamino)-2-(3-Fluorobenzoyl)Acrylonitrile is a high-purity, light-sensitive chemical intermediate with a distinct α,β-unsaturated nitrile structure. This compound is valued for its role as a versatile building block in advanced organic synthesis, enabling the construction of complex heterocyclic and pharmaceutical scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing kinase inhibitory activity.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, leveraging its fluorinated benzoyl moiety for enhanced biological activity and metabolic stability.
• Organic Synthesis Building Block: Serves as a Michael acceptor or a dipolarophile in cycloaddition reactions (e.g., [3+2] cycloadditions) to construct pyrrole, pyrazole, or other nitrogen-containing heterocycles.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating specialized polymers with unique optical or electronic properties.
• Chemical Biology Probe Development: Utilized in crafting molecular probes for studying enzyme mechanisms or protein-ligand interactions due to its electrophilic β-carbon.

Basic Information

Product Name	(E)-3-(Dimethylamino)-2-(3-Fluorobenzoyl)Acrylonitrile
CAS No.	96249-05-7
Molecular Formula	C₁₂H₁₁FN₂O
Molecular Weight	218.23 g/mol
Synonyms	2-Propenenitrile, 3-(dimethylamino)-2-(3-fluorobenzoyl)-, (2E)-; (E)-3-(Dimethylamino)-2-(3-fluorobenzoyl)acrylonitrile; 3-(Dimethylamino)-2-(3-fluorobenzoyl)acrylonitrile; (E)-3-Dimethylamino-2-(3-fluorobenzoyl)acrylonitrile; 2-(3-Fluorobenzoyl)-3-(dimethylamino)acrylonitrile; 3-Fluoro-β-(dimethylamino)-α-cyanocinnamaldehyde; NSC 339586
EINECS	Contact for details

Quality Control

Our (E)-3-(Dimethylamino)-2-(3-Fluorobenzoyl)Acrylonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.