Description

L-Proline, 4-Hydroxy-5-(Hydroxymethyl)-, (4S,5R)- (9Ci) CAS NO 95863-87-9 is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry and functionalized proline backbone. This compound is a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules. It is essential for research and production in medicinal chemistry, peptide synthesis, and as a precursor for complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used to incorporate modified proline residues into peptide chains to alter conformation, stability, and biological activity.
• Medicinal Chemistry Research: Serves as a scaffold for drug discovery programs targeting various enzymes and receptors.
• Biochemical Research: Employed in studies of enzyme mechanisms, protein folding, and as a standard for analytical methods.
• Asymmetric Synthesis: Utilized as a catalyst or auxiliary in stereoselective chemical transformations.

Basic Information

Product Name	L-Proline, 4-Hydroxy-5-(Hydroxymethyl)-, (4S,5R)- (9Ci)
CAS No.	95863-87-9
Molecular Formula	C7H13NO4
Molecular Weight	175.18 g/mol
Synonyms	(4S,5R)-4-Hydroxy-5-(hydroxymethyl)-L-proline; (2S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)proline; 4-Hydroxy-5-(hydroxymethyl)-L-proline; Hydroxymethylproline; A Proline derivative; (4S-trans)-4-Hydroxy-5-(hydroxymethyl)-2-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of L-Proline, 4-Hydroxy-5-(Hydroxymethyl)-, (4S,5R)- (9Ci) adheres to stringent quality management protocols. The material is manufactured under controlled conditions and undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure batch-to-batch consistency and high chemical purity. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and specific rotation are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.