Description

1-Chloroestradiol is a halogenated derivative of the natural estrogen hormone, estradiol, where a chlorine atom is introduced at the 1-position of the steroid nucleus. This structural modification is of significant interest in pharmaceutical research for developing novel steroid-based compounds with potential therapeutic applications. It serves as a critical synthetic intermediate and reference standard for researchers in the fields of medicinal chemistry, endocrinology, and steroid biochemistry.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel steroid derivatives for drug discovery and development.
• Biochemical Research: Used as a reference standard and probe in studies investigating estrogen receptor binding, metabolism, and structure-activity relationships (SAR).
• Medicinal Chemistry: Acts as a precursor for creating modified estradiol analogs with potential altered biological activity, selectivity, or pharmacokinetic profiles.
• Academic & Institutional Research: Employed in university and laboratory settings for fundamental research on steroid hormone action and chemical modification.
• Reference Material: Provides a characterized compound for use in analytical method development, validation, and quality control within research and development.

Basic Information

Product Name	1-Chloroestradiol
CAS No.	95846-28-9
Molecular Formula	C18H23ClO2
Molecular Weight	306.83 g/mol
Synonyms	1-Chloroestra-1,3,5(10)-triene-3,17β-diol; 1-Chloro-17β-estradiol; 1-Chloro-3,17β-dihydroxyestra-1,3,5(10)-triene; Estra-1,3,5(10)-triene-3,17-diol, 1-chloro-, (17β)-; 1-Chloro-17β-estra-1,3,5(10)-triene-3,17-diol
EINECS	Contact for details

Quality Control

Our 1-Chloroestradiol is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.