Description

Dydrogesterone CAS NO 152-62-5 is a synthetic progestogen hormone, chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. It is a critical active pharmaceutical ingredient (API) valued for its oral activity and selective action on the endometrium, making it a key therapeutic agent. This compound is primarily required by pharmaceutical manufacturers for the production of hormone replacement therapies (HRT) and treatments for gynecological disorders such as endometriosis, dysfunctional uterine bleeding, and for supporting pregnancy.

Application

• Pharmaceutical API: Primary use as the active ingredient in hormone replacement therapy (HRT) medications for managing menopausal symptoms.
• Gynecological Treatments: Formulation into drugs for treating endometriosis, secondary amenorrhea, and dysfunctional uterine bleeding.
• Fertility & Pregnancy Support: Used in luteal phase support and for the prevention of habitual and threatened abortion.
• Hormone Regulation: Key component in regimens for regulating the menstrual cycle and inducing secretory transformation of the endometrium.
• Drug Development & Research: Serves as a reference standard and key intermediate in pharmaceutical R&D for novel progestogen-based therapies.

Basic Information

Product Name	Dydrogesterone
CAS No.	152-62-5
Molecular Formula	C21H28O2
Molecular Weight	312.45 g/mol
Synonyms	9β,10α-Pregna-4,6-diene-3,20-dione; 6-Dehydro-9β,10α-progesterone; 9β,10α-Progesterone; Isopregnenone; Duphaston® (Brand Name); Retroprogesterone; (9β,10α)-Pregna-4,6-diene-3,20-dione
EINECS	205-803-7

Quality Control

Our Dydrogesterone is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Every batch undergoes comprehensive analytical testing including identification, assay, and impurity profiling to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided for each shipment, confirming specifications for identity, potency, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.