Description

Premarin is a complex, conjugated estrogen preparation derived from natural sources, widely recognized for its standardized hormonal activity. This product is critical for hormone replacement therapy (HRT) and various clinical research applications, addressing conditions related to estrogen deficiency. It is an essential active pharmaceutical ingredient (API) for pharmaceutical manufacturers, research institutions, and compounding pharmacies focused on women's health and endocrine studies.

Application

• Hormone Replacement Therapy (HRT): Primary API in formulations for managing menopausal and postmenopausal symptoms such as hot flashes, vaginal atrophy, and osteoporosis prevention.
• Pharmaceutical Manufacturing: Used as the key bioactive component in the production of tablets, creams, and vaginal rings.
• Clinical Research: Serves as a reference standard and investigational agent in endocrine, metabolic, and oncological studies.
• Compounding Pharmacy: Utilized by specialized pharmacies to prepare customized dosage forms for specific patient needs.
• Veterinary Medicine: Applied in certain veterinary hormonal therapies and reproductive health management.

Basic Information

Product Name	Premarin
CAS No.	12126-59-9
Molecular Formula	Complex mixture of conjugated estrogens (primarily sodium estrone sulfate and sodium equilin sulfate)
Molecular Weight	N/A (Mixture)
Synonyms	Conjugated Estrogens; Conjugated Equine Estrogens (CEE); Estrone Sulfate Sodium Salt; Equilin Sulfate Sodium Salt; Premarin® (Brand Name); Sodium Estrone Sulfate; Sodium Equilin Sulfate; CE
EINECS	Contact for details

Quality Control

Our Premarin is manufactured and tested under strict quality systems to ensure it meets the rigorous standards required for pharmaceutical use. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and conformance to relevant specifications. We adhere to current Good Manufacturing Practices (cGMP) and can support compliance with major pharmacopeial standards such as USP (United States Pharmacopeia) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its sensitivity, the product should be handled under an inert atmosphere to minimize oxidation and kept in moisture-resistant packaging.

Specification

Item	Specification
Description	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (Total Conjugated Estrogens)	90.0% - 110.0% (on dried basis)
Specific Rotation	Contact for details
Loss on Drying	≤ 5.0%
Sulfated Ash	Contact for details
Related Substances (HPLC)	Meets established limits
Microbiological Control	Meets USP <61> and <62> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.