Description

7-Azidoketanserin is a chemically modified derivative of the serotonin receptor antagonist ketanserin, featuring an azido functional group. This compound is a critical intermediate and research tool in the development of novel pharmacological probes and potential therapeutic agents targeting serotoninergic pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers engaged in neuroscience, receptor biochemistry, and medicinal chemistry.

Application

• Pharmacological Research: Acts as a key intermediate in the synthesis of novel, high-affinity ligands for serotonin (5-HT2A) receptor studies.
• Photoaffinity Labeling: The azido group enables its use as a photoaffinity labeling agent for mapping serotonin receptor binding sites and studying protein-ligand interactions.
• Medicinal Chemistry: Serves as a versatile building block for creating chemical libraries aimed at discovering new central nervous system (CNS) active compounds.
• Bioconjugation: Used in click chemistry applications for the selective tagging and modification of biomolecules in biochemical assays.
• Reference Standard: Employed as an analytical standard in quality control and method development for related pharmaceutical compounds.

Basic Information

Product Name	7-Azidoketanserin
CAS No.	95653-71-7
Molecular Formula	C22H22FN7O2
Molecular Weight	435.46 g/mol
Synonyms	7-Azido-ketanserin; 3-[2-[4-(7-Azido-4-fluorobenzodioxan-5-yl)piperidin-1-yl]ethyl]quinazoline-2,4-dione; Azidoketanserin; 4-Fluoro-7-azido-5-[1-[2-(2,4-dioxo-1H-quinazolin-3-yl)ethyl]piperidin-4-yl]-2,3-dihydro-1,4-benzodioxine
EINECS	Contact for details

Quality Control

Our 7-Azidoketanserin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed in a dry, inert atmosphere to maintain stability. Handle and store in accordance with all applicable laboratory safety regulations.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.