Description

2-Isocyanato-5-(Trifluoromethyl)Pyridine is a specialized heterocyclic isocyanate building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the isocyanate group combined with the electron-deficient nature of the trifluoromethyl-substituted pyridine ring, enabling the construction of complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for producing high-performance polyurethanes, polyureas, and other specialty polymers with tailored thermal and chemical resistance.
• Ligand & Catalyst Development: Employed to synthesize novel pyridine-based ligands for transition metal catalysis, useful in asymmetric synthesis and coupling reactions.
• Chemical Biology Probes: Facilitates the creation of activity-based probes and bioconjugation reagents for studying biological pathways and protein labeling.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Isocyanato-5-(Trifluoromethyl)Pyridine
CAS No.	95651-16-4
Molecular Formula	C7H3F3N2O
Molecular Weight	188.11 g/mol
Synonyms	5-(Trifluoromethyl)pyridin-2-yl isocyanate; 2-Isocyanato-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-pyridyl isocyanate; 2-Pyridineisocyanate, 5-(trifluoromethyl)-; Isocyanic acid, 5-(trifluoromethyl)-2-pyridyl ester
EINECS	Contact for details

Quality Control

Our 2-Isocyanato-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production use. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.